To discuss more about this job opportunity, please reach out to Chitrank Rastogi (LinkedIn URL - https://www.linkedin.com/in/chitrank-rastogi-55119a102/), email your updated resume at Email - chitrank.rastogi@collabera.com or give me a call at (425) 523-1648. Thank you!

Job Description:
Job Roles & Responsibilities:

• We utilize cutting-edge genomic techniques to transform human genetics data into drug targets and to identify pathogenetic mechanisms.
• We apply high-throughput functional genomic screening approaches to in vitro and in vivo preclinical models with diverse molecular and phenotypic readouts.
• We focus on patient centric models, developing various tools utilizing induced pluripotent stem cell (iPSC) derived cell types.
• We perform hypothesis-driven research for target validation and execute mechanistic studies utilizing these complex models.
• We have an exciting opportunity for a talented and highly motivated Scientist to join our collaborative team of geneticists, molecular and cellular biologists, and computational biologists.
• Applicants should have broad laboratory research experience using cell and molecular biology techniques.
• Open communication and curiosity are essential.
• The candidate is expected to operate in a fast-paced, multi-disciplinary setting and must be able to execute multiple research projects in parallel.
• This position requires consistent weekend and/or holiday work within the lab.
• This position also requires performing administrative and managerial tasks within the lab, up to 25%.

Key Responsibilities:

• Perform routine cell culture work to maintain and expand cell lines, including induced pluripotent stem cells (iPSCs)
• Perform differentiation of iPSCs towards cell types of interest (e.g. retinal cells, immune cells)
• Perform CRISPR/Cas functional genomics research based on lentiviral and RNP delivery methods
• Participate in cross-functional target identification and validation projects to support early drug discovery efforts in immunology and ophthalmology
• Develop cell-based functional assays relevant to disease biology
• Perform arrayed and pooled CRISPR screens using fluorescent cell sorting and high content imaging assays
• Collaborate extensively with scientists across diverse functional and therapeutic areas in a matrixed research environment
• Communicate and present project designs and results clearly, both to individual stakeholders and in group settings
• Perform routine managerial tasks within the lab, such as coordinating maintenance schedules, liaise with facilities sustain operations, organize lab-wide

Qualifications:

• BS, MS, and/or PhD in Immunology, Molecular Biology, Cell Biology, Biomedical Engineering, or in a related discipline
• BS with 5+ years’ experience in a lab setting, MS with 2+ years, or PhD with 0+ years’ experience in a lab setting, either within an industry and/or academic setting
• Experience with in vitro cell culture, aseptic technique, and development of cell-based assays is required, minimum 1 year
• Experience in flow cytometry, immunofluorescence, and/or protein assays (e.g. ELISA, Western Blot) is expected, minimum 1 year
• Experience in transfection, nucleofection, and viral transduction is a plus
• Experience within immunology, neuroscience, and/or ophthalmology research is a plus
• Knowledge or Experience in CRISPR systems is a plus
• Ability to learn new skills and apply them in a fast-paced research environment is a must
• Creativity, problem-solving, organizational skills, and attention to details are expected
• Strong communication and collaboration skills are essential.
• Ability to work independently as well as in a team is a must.