Industry: Pharmaceutical 

Job Title:  Scientist - (CYP450) - Onsite

Location: South San Francisco, CA 94080

Duration: 06-12+ Months (+Potential for extension)

Pay Range: $45-$58/hr

• The Quantitative, Translational & ADME Sciences (QTAS) department is seeking a highly motivated fulltime contract Scientist to join the In Vitro ADME Sciences group (IVAS).  
• The successful candidate will work in collaboration with other team members to characterize the CYP Induction properties of candidate drug molecules and may work on other in vitro ADME assays.  
• QTAS works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.
• In this role, you will be a scientist with hands-on experience in conducting in-vitro ADME assays primarily including CYP450 induction assays to characterize candidate drug molecules for potential to induce CYP450 enzymes.  
• Furthermore, you will provide support to project teams to enhance mechanistic understanding of complex drug-drug interactions.

• Routinely conduct (hands-on) evaluation of CYP450 induction
• Conduct qPCR assay
• Interpretation of in vitro CYP induction data derived from assays in human hepatocytes or reporter gene systems
• Perform human hepatocytes cell culture, seeding and maintenance
• Perform cell viability assessments and use  microplate reader to measure endpoint
• Contribute to invitro ADME assay design and discussions
• Analyze data and maintain detailed, accurate and comprehensible study documentations
• Use BioELN and GraphPad Prism for data analysis

• BS or MS in with 1-3 + (BS) relevant exp. 
• CYP induction assay
• In vitro ADME
• qPCR
• Cell culture
• liquid handling system
• Some weekend work may be required - overtime will be paid as an hour and a half